In total, 175 SNPs in 17 genes on nine chromosomes were tested for association. Several SNPs across six genes showed evidence for association (P < 0.05) with one or both of the phenotypes analyzed. The strongest association was between rs1229984, a non-synonymous coding SNP in ADH1B, and DSM-IV symptom count (P = 0.0003). This SNP was also associated with max drinks (P = 0.0004). For both phenotypes, minor alleles were associated with less severe drinking behavior. In addition, SNP rs8187974 in ALDH1A1 was also nominally associated with both phenotypes. Finally, there was a haplotype of six contiguous and correlated SNPs in ALDH1A2 that were all nominally associated with max drinks (P = 0.01). Table 1 shows the complete single SNP association results for both phenotypes analyzed.
