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Chunk #20 — DISCUSSION

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Identification of ten loci associated with height highlights new biological pathways in human growth.
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When we remove the 12 validated height variants (and nearby correlated SNPs) from the meta-analysis results, the number of low P values still exceeds the null expectation (Fig. 2a, filled squares). Furthermore, the 10,000 SNPs with the best P values also showed excess evidence of association in an independent meta-analysis18, even when all loci known to be associated with height were excluded (Fig. 2b). These results indicate that there are other associations with common alleles yet to be discovered, but that our meta-analysis is not sufficiently powered to identify these associations because the effect sizes are small.