We included summary statistics from two existing GWAS of eating disorder phenotypes where particiants were primarily of European ancestry (Wade et al., 2013, Watson et al., in press) and six existing GWAS of substance use-related phenotypes using data only from individuals of European ancestry (Demontis et al., 2019, Hancock et al., 2017, Kranzler et al., 2019, Liu et al., 2019, Pasman et al., 2018, Walters et al., 2018). The eating disorder phenotypes (Table 1) included a diagnosis of AN (which was further parsed into AN with binge-eating or AN without binge-eating), and a BN factor score derived from the Eating Disorder Examination (EDE; Fairburn and Cooper, 1993). The EDE is a well-established, structured clinical interview used to determine eating disorder diagnoses. We did not examine BN or BED diagnoses because there are currently no published GWAS of either disorder; thus, the EDE-BN factor score represents the closest to a GWAS of BN available. Substance use-related phenotypes ranged from typical use (e.g., drinks per week, smoking initiation, and cannabis initiation) to abuse/dependence (i.e., AUD, ND, and cannabis use disorder [CUD]). Table 2 provides individual study details.
