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Chunk #92 — Methods — Expression quantitative trait loci (eQTL) — Functional annotation of eQTLs — Overlap with the GWAS catalogue

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Common genetic variation drives molecular heterogeneity in human iPSCs.
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significantly associated variants, and kept all associations with P < 1x10-06 for these traits. This approach yielded a filtered set of 9,562 associations for 6,059 variants with 358 diseases and traits. Each variant position was then parsed for trait overlap (all traits associated to the given variant). If a variant - trait association was reported multiple times (e.g. by different studies), the most significant association was kept.