Chunk #6 — Materials and Methods — Genome-wide Genotyping and Imputation

Source

Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study.

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Genotype imputation of SNPs and insertion/deletion polymorphisms (indels) was used to expand coverage and increase statistical power.[18] Imputation was conducted in AAs and EAs, separately, using IMPUTE2[18] with reference to the ALL 1000 Genomes reference panel[19] (see S1 Methods).