Recently, Huang et al. [6] demonstrated that assuming linkage equilibrium between tight linked markers where strong LD exists may cause apparent over-sharing of multipoint IBD among affected sibs and thus result in false-positive evidence for linkage. Here in this workshop, Genetic Analysis Workshop 14 (GAW14), we used the simulated data to further explore the effect that LD exerts in causing an excess of false-positive results. The workshop data afforded a more realistic situation upon which to study effects of LD than was covered by Huang et al. [6], because the data were simulated to represent a complex disease model and a large set of markers were available for further examination of the possible effects that LD can have upon multipoint linkage analysis.
