Quantitative trait analyses were carried out in the UK, DGI and FUSION samples for the 11 SNPs taken forward to stage 3. We tested BMI, quantitative glycemic traits (fasting and 2 hour glucose and insulin, HOMA-IR), lipid traits (total, HDL and LDL cholesterol, and serum triglycerides) and blood pressure (systolic and diastolic), where available, for association using an additive genetic model (Supplementary Methods).
