classified as “exposed” or “non-exposed.” Longitudinal birth cohort studies, which can include prospective measures of environmental exposures along with detailed phenotype data and genome-wide data, may be one promising avenue for conducting GEWIS in the future. Moreover, the growing interest in the concept of the “exposome,” environment-wide association studies (EWAS) and ways to systematically identify relevant environmental factors (see for example142,143) could yield new insights to guide GEWIS in the future.