We used LDhub or local LDSC [25] to calculate genetic correlations (rg) between POU and 935 other traits or diseases (852 from LDHub and 83 local) [25]. Local traits were selected based on previously known phenotypic associations between OUD and other substance use disorder phenotypes and related traits (e.g., cannabis use disorder, various measures of impulsivity) not available on LDhub. We used the standard Benjamini–Hochberg false discovery rate correction (FDR 5%) to correct for multiple testing. We also calculated a Bonferroni correction for 935 comparisons (p < 5.35E−05); however, this correction is overly conservative because many of the 935 traits are highly correlated with one another.
