Chunk #16 — Current Status of Drug Labeling and Pharmacogenomic Testing Guidelines — Guidelines and Labeling for Carbamazepine

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Pharmacogenomic testing for neuropsychiatric drugs: current status of drug labeling, guidelines for using genetic information, and test options.

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There are other HLA alleles that also demonstrate evidence for the association with carbamazepine-induced hypersensitivity reactions, including mild maculopapular eruptions, drug hypersensitivity syndrome, SJS, and TEN. One additional variant allele, HLA-A*3101, was first identified in Han Chinese, followed by identification among Japanese, European, and Korean populations.30 Currently, recommendations provided by the CPIC and in the FDA labeling do not include these additional HLA variants.