drug mechanisms of action and rational drug repurposing39. Rare variants, discovered by large scale sequencing efforts, can also be included in these analyses, particularly the known recurrent Copy Number Variations in Autism and Schizophrenia40. These are complemented by ongoing large scale sequencing efforts in these disorders. Although rare mutations are only found in a small percentage of cases with most common disorder4142, integrative pathway analysis including common and rare variants might increase power to detect statistically significant enriched pathways.
