The establishment of a μNeurocircuitry model using human neurons derived from patients with known genetic background provides the opportunity to ultimately pursue personalized studies of neuropsychiatric disorders, such as schizophrenia, drug addiction or Parkinson's. Genome wide association studies have identified numerous polymorphisms that render carriers at greater risk for such diseases35,36. By using human neurons with known risk alleles of a specific disease, we can study the role of a selected allele in mediating disease in a given neuronal subtype with its circuit connections.
