The measure of assortativity showed significant differences in functional networks between healthy and AD networks, which confirms the efficacy of the assortativity measure in our work [32]. Network topology parameters were used in recent studies to distinguish between healthy elderly and AD subjects [68,69,70]. As far as we know, most recent studies focus on local and global efficiency clustering coefficients and path length to investigate age-related differences in functional brain networks. Hence, our work proposed to examine the efficacy of node strength betweenness centrality, and assortativity to analyze age-related differences in connectivity and network topology of the human brain. Our study provides additional support for the investigation of the effect of natural aging on memory by utilizing the proposed network features.
