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Chunk #18 — Results — LTP fails to stabilize in slices from BAF53b mutant mice

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The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory.
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this timepoint in Baf53b+/− het mice and wildtype littermates. Wildtype mice showed a clear, TBS induced increase in the number of densely labeled pCofilin puncta co-localized to PSD95 seven minutes following TBS, while the Baf53b+/− het mice did not show a TBS induced increase in the double labeled puncta (Fig 6D). This difference was not due to any changes detected in PSD95 volumes or intensities (Fig 6E), suggesting that the post synaptic terminal between the two groups is structurally similar.