the biology of a given cell type. Moreover, they are disproportionally enriched for genetic risk variants compared to typical enhancers, and the enrichment is biased toward disease-relevant cell types. These results further support the notion that variants that influence cell-type-specific gene regulation are major contributors to common disease risk, and extend this concept to demonstrate that altering the expression of genes under exquisite regulation can frequently lead to increased risk. Enhancer cluster identification provides a means of detecting highly regulated genes and may help to prioritize noncoding variants that are likely to be functional.
