In Table 4, marker information, nominal p-values, and effect sizes are provided for the 6 independent SNPs (in bold) from 5 DA genes that were significant after permutation testing with either AD or a quantitative alcohol-related trait. All other SNPs in this table did not pass permutation testing. Effect sizes are listed as OR for AD and as β, the regression coefficient, for the quantitative traits. We used an additive model in which each additional minor allele will increase (+) or decrease (−) the units of measure (symptoms, years, scores, etc.) by the amount of the coefficient. For example, in rs11575542, β = 0.80 for DDsx, which means that each additional minor allele will increase DD symptoms by 0.80 of a symptom. β Values are more difficult to interpret for ISENS, TOLMX, and the factor score because they are log transformed and for ADHDsx and NS because their units have been rescaled. For information on the full list of SNPs, see Table S1. Three SNPs (1 in DRD4 and 2 in SLC6A3) were associated with AD, 2 SNPs (in DRD5 and TH) with WDSFS, and 1 in DRD3 with ISENS.
