Chunk #12 — MATERIALS AND METHODS — Statistical model — QuantiSNP: an Objective Bayes Hidden-Markov Model — Hierarchical prior specification

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QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.

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We use standard normal-gamma conjugate priors for the emission model parameters which allows for efficient analytic integration in posterior calculations, 5 where τ,α,β,m are set ‘objectively’ (see below).