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Chunk #27 — Discussion

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Nicotinic receptor gene variants influence susceptibility to heavy smoking.
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smoking 30 or more cigarettes per day were nicotine dependent using the FTND criteria of a score of 4 or more. Similar findings were seen in former smokers. This comparison of number of cigarettes per day and FTND score in the COGEND population and a previous analysis of cigarettes per day with DSM-IV defined nicotine dependence (6) indicate that the majority of our heavy and light smokers would be classified as nicotine dependent and non-dependent, respectively.