Age of onset comparisons are shown in Kaplan-Meier Plots (Figure 1a–c). Each of these shows significant effects of comorbidity by Log-rank Test (p < 0.001 for each). The plots do not include a covariate effect but we have also achieved similar results by the Cox model adjusting for covariate effects (p < 0.001 for each; Table 2). The statistical effect of comorbidity is generally greatest in the development of Severe AUD and least in Mild AUD based on the hazard ratios in the different comorbidity types (Table 2). The three groups are significantly different from each other in the strength of the comorbidity effect (Severe vs Moderate, p < 0.001; Severe vs Mild, p < 0.001; Moderate vs Mild, p < 0.001).
