frontal cortex, and hippocampus) but not for most, and not as high a probability as for PPP6C. For FURIN, the null hypothesis of neither trait being associated in this region has the highest posterior probability across all tested brain tissues (Fig. 5, Supplementary Table 15), which is consistent with (1) a single variant (rs17514846) driving the GWS gene-based association with OA, (2) no significant evidence for differential gene expression in the S-PrediXcan analyses, (3) limited evidence for this variant as an eQTL in brain tissues (Supplementary Table 16).
