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Chunk #79 — III. Selected Methodological Issues — A. Genotyping using pooled DNAs

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
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Gentyping for genome wide association studies can be performed in either individual samples or in pools of DNAs from individuals with the same racial/ethnic background and the same phenotype. Pooling strategies have several advantages. Pooling fits well with association genetics, can efficiently perform allele typing, preserve confidentiality and reduce costs [10, 122–124].