Finally, to increase our confidence in the scoring results, we simulated three types of phenotypes. First, we simulated a normally-distributed phenotype with no genetic association, which we refer to as “Random.” Second, we simulated phenotypes from 10,000, 50,000, and 100,000 causal SNPs under an additive model with normally distributed regression coefficients. Third, we simulated phenotypes from 10,000, 50,000, and 100,000 SNPs under an additive model with uniformly distributed regression coefficients. The phenotype in both the normal and uniform scenarios was simulated to be 17% heritable, in line with expectations based on the GCTA analyses reported in the current study.
