rs2057763 is an intergenic SNP 36.7 kb from the closest gene on chromosome 7p15 encoding NFE2L3, a relatively poorly characterized NFE2L2 homolog, recently recognized to play a key role in inflammation (35). Probes to NFE2L3 were not analyzed in the primary analysis because of risk of SNP hybridization artifacts. We therefore performed quantitative polymerase chain reaction (qPCR) on both the 3′ untranslated region and exons 1 and 2 of NFE2L3 in monocytes from a randomly selected subset of 84 individuals after IFN-γ and observed a cis-eQTL for rs2057763 (fig. S11), supporting NFE2L3 as the probable driver behind this network.
