Preliminary analyses evaluated genotype differences in demographic and substance use variables. Genotype and sex differences in self-administration outcomes were evaluated using analysis of variance and chi square difference tests. Descriptive summaries of aBAC profiles were generated on a per-participant basis and by OPRM1 group using model-projected aBAC values. Associations of ASQ variables and subjective alcohol responses with CASE outcomes were evaluated with bivariate correlations and chi square tests, respectively. Associations of OPRM1 with subjective responses were examined based on bivariate associations with post-priming and peak subjective scores, as well as with repeated-measures ANOVA. Because these two methods did not lead to substantive differences in the conclusions, bivariate correlations are reported for simplicity.
