Protein expression studies have been conducted in various brain regions including the occipital cortex,127 hippo campus132 and cerebellum.133 Again, while such studies suggest that several pathways may be associated with ARBD, relevant protein expression studies in patients with uncomplicated alcoholism show dysregulation of key energy-regulating and metabolic proteins, notably those involved in thiamine-dependent cascades in prefrontal gray and white matter,134,135 cerebellar vermis133 and corpus callosum.136,137 These findings lend weight to the continuum hypothesis of ARBD, WE and KS.
