A comprehensive evaluation of 17,601 autosomal genes provided by VEGAS yielded a genome-wide significant association (α = 2.87 × 10−6) with both endophenotypes for MYEF2, myelin expression factor 2, p ≤ 6.79 × 10−7, a gene on chromosome 15. The protein encoded by MYEF2 is a repressor of transcription of the myelin basic protein gene (MBP). Gene Ontology annotations related to MYEF2 include RNA binding and nucleotide binding. The next smallest p value was 7.50 × 10−5.
