The function of FAM78B, associated with progression from cocaine use to dependence, is not well understood but it is highly expressed in the brain [52] and interacts with several other proteins with diverse functions [53]. According to the STRING protein-protein interaction database (as https://string-db.org) [54], the proteins with which it is predicted to interact include ones related to mitochondrial function (ATP5F1), neurofilament network integrity (SNCG), and NOTCH signaling (XXYLT1).
