the contribution of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\rho _b^2h_2^2/h_1^2$$\end{document}ρb2h22/h12 to the RA of PGS in individuals of SAS and EAS might be even larger if evaluated across continents than reported in this study. A recent study by Durvasula et al.12 suggested that ~50% of the heritability is captured by European specific variants when a trait is under moderate negative selection, thus limiting the upper bound of prediction accuracy in AFR for example when using European-derived GWAS summary statistics. Our results based on common variants also show a RA <50% in AFR but we demonstrate that this reduction is mostly explained by MAF and LD differences at common causal variants and not necessarily by population specific causal variants. The latter conclusion is further supported by large genetic correlations observed between EUR and non-EUR ancestries36, which overall suggests that causal variants underlying common genetic variation identified in European ancestry GWASs are mostly shared across continents.
