Chunk #10 — MATERIALS AND METHODS — Linkage disequilibrium

Source

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

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Linkage disequilibrium (LD) between SNPs was calculated for cases and controls using the verbose option of ldmax (Abecasis and Cookson, 2000). Signed D’ coefficients were calculated to retain LD phase information (Saccone et al., 2006). LD plots were generated using a custom program.