Those meeting lifetime criteria for DSM-IV cannabis use disorders experienced greater disability – 63.7% of those with cannabis use disorders reported disability while only 44.5% of those not meeting criteria reported disability. Those individuals with BD who reported comorbid cannabis use disorders were 2.2 times more likely to report disability in life-functioning attributable to BD and also a modest increased probability of attempting suicide. Mixed episodes were more common in those with a lifetime history of DSM-IV cannabis use disorders. Importantly, even after controlling for all sociodemographic, substance use and psychiatric covariates, those with DSM-IV cannabis use disorders were 1.8 times more likely to report disability due to BD than those without a history of cannabis use disorders.