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Chunk #16 — RESULTS — Effect of VAR on Alcohol and Water Intake Following the Second Alcohol Deprivation Cycle

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Varenicline Reduces Alcohol Intake During Repeated Cycles of Alcohol Reaccess Following Deprivation in Alcohol-Preferring (P) Rats.
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With regard to alcohol intake during the first 5 days of the alcohol reaccess period, there was a significant effect of treatment F (3, 42) = 6.4, p<0.01, no effect of day, and no treatment X day interaction (Fig. 3). Dunnett’s multiple comparisons against a single mean (VEH) revealed that VAR, in doses of 0.5, 1.0, and 2.0 mg/kg BW, each reduced alcohol intake (p<0.05, p<0.001, and p<0.01, respectively) (Fig. 3).