High genetic correlations were observed across the EUR, AFR and LA ancestries (Fig. 1e and Supplementary Table 4). The genetic-effect correlation (ρge) is 0.71 (s.e. 0.09, P = 6.16 × 10−17) between EUR and AFR, 0.85 (s.e. 0.09, P = 3.14 × 10−22) between EUR and LA, and 0.88 (s.e. 0.18, P = 1.58 × 10−6) between AFR and LA. The genetic-impact correlation (ρgi) is 0.67 (s.e. 0.07, P = 2.78 × 10−21) between EUR and AFR, 0.86 (s.e. 0.09, P = 3.52 × 10−20) between EUR and LA, and 0.72 (s.e. 0.16, P = 9.63 × 10−6) between AFR and LA. The estimates involving smaller study populations were not robust (Bonferroni P > 0.05).
