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Chunk #18 — Results

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Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.
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Table 3 provides further characterization of early-experience patterns for respondents reporting moderate-to-intense reactions. Cases (regular smokers) exhibited enhanced sensitivity to cigarette smoking, with a larger proportion reporting more positive and more negative experiences than controls (never-smokers). With respect to race differences, only global displeasurable and relaxation effects reached significance in comparisons that took into account smoking status; in comparisons limited to just smokers, a significantly larger proportion of African Americans endorsed global pleasurable (P < 0.002) and global displeasurable experiences (P < 0.003), along with pleasurable rush or buzz (P < 0.002), dizziness (P < 0.004), relaxation (P < 0.001) and difficulty inhaling (P < 0.02).