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Chunk #0 — Introduction

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Alcohol Use Disorder Polygenic Score Compared With Family History and ADH1B.
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Alcohol use disorder (AUD), characterized by excessive and uncontrolled alcohol consumption despite adverse social, mental, and health consequences, represents a substantial public health challenge.1 In 2021, 11.2% of US adults and, remarkably, 2.9% of youths aged 12 to 17 years had AUD.2 Beyond the direct consequences of AUD on mental and physical health, individuals with the disorder have increased risk of more than 200 diseases1 and 4.7 times greater risk of mortality.3 Moreover, adverse social and mental outcomes have been observed for family members of individuals with AUD, especially children, which can exert a lasting effect on the health of future generations (eg, fetal alcohol spectrum disorders).