Vojta et al. 2016) or TET1 demethylase (Choudhury et al. 2016; Liu et al. 2016a, b; Xu et al. 2016) to add or remove DNA methylation marks, or other chromatin modifying enzymes such as G9a or SUV39H1 (Snowden et al. 2002). These reagents will be important in establishing the role and importance of such epigenetic changes in disease progression either by introducing them into healthy cells, or reverting effects observed in disease models.
