Among all individuals, the strongest association with FEV1 was with rs204652 in MACRO domain containing 2 (MACROD2) on chromosome 20. SNP rs17133553 in Contactin 5 (CNTN5) on chromosome 11 was the second top locus for association with FEV1 and third for FEV1/FVC ratio. SNP rs803450 in Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) on chromosome 6 showed association with FEV1 in all individuals. For FEV1/FVC ratio in all individuals the strongest association was with rs3887893 in ATP-binding cassette, sub-family C, member 1 (ABCC1) on chromosome 16, the second strongest signal was for rs11155818 in estrogen receptor 1(ESR1) on chromosome 6.
