We identified terms for cholinergic nicotinic receptor genes (CHRN) that were significant independent of the threshold used to select the SNPs. Three molecular function and one cellular component terms were significant for both OZALC-NAG and SAGE, regardless of the threshold for SNPs considered (Table 3 and Table S2). These four terms were replicated in ARIC, again for both p-value thresholds applied to SNP selection. Despite specificity differences in the genes grouped by each term, all of them contain a majority of the nicotinic (CHRN) and muscarinic (CHRM) cholinergic receptor subunit genes, and other closely related genes (Figure 1).
