Interestingly, a large percentage of these common differentially expressed transcripts (48%, or 5,500 probes) are poorly annotated, including probes not mapped to the human genome (HG19; http://genome.ucsc.edu/cgi-bin/hgGateway), mapped to contig sequences, or not mapped to known GENCODE genes21. Approximately 10% of these transcripts had very high correlation with the co-expression modules identified above (Pearson r > 0.7; Supplementary Table 6). For example, 38 transcripts demonstrated high correlation with the striatal module (M6), and 87 transcripts with the oligodendrocyte-associated module (M12; Fig. 3c), providing anatomical ‘guilt-by-association’ annotation of these genes of previously unknown function for selective roles in striatal and myelin function, respectively.
