Our study has several strengths. First, this is the first PWAS of depression using the largest and deepest reference human proteomes and summary statistics from the latest GWAS of depression. Second, this is the first study to our knowledge that examined both the mRNA and protein levels in depression through both a PWAS and TWAS. Finally, we have a replication PWAS using an independent GWAS and independent reference human brain proteomic and genetic data.
