MCI was associated with a substantially increased risk of developing AD and a greater rate of cognitive decline [172]. Persons with MCI had entorhinal cortex and hippocampal atrophy and disruption of parahippocampal white matter fibers [173]. They also had reductions of fractional anisotropy in posterior white matter regions [174]. Finally, among persons with MCI, both baseline entorhinal cortex hippocampal volume and rate of change in entorhinal cortex and hippocampal volume are associated with risk of AD [175–177]. MCI was also associated with changes in resting state fMRI [178].
