the rankings are the same as by P-value alone [for more information see the discussion of normalized weights in (4)]. When deciding on a score, it is helpful to use a frame of reference. By default, we prioritize SNPs in genes one order of magnitude higher than those not in or near genes, and missense SNPs one order of magnitude higher than those in introns. In Saccone et al. (4), we conducted a sensitivity analysis to demonstrate that the GIN prioritization results are not sensitive to small changes in prioritization scores.
