et al., 2007; Tartaglia et al., 2008]. Physical height is increased to a greater extent than in 47,XXY [Linden et al., 1995]. Individual case studies of clinical MRI findings in individuals with 48,XXYY have reported white matter hyperintensities in a 48,XXYY male with autism [Jha et al., 2007], and in a 9-year-old with premature puberty [Garcia-Cazorla et al., 2004]; and frontoparietal cortical atrophy on CT scan in a 22-month-old toddler with multiple developmental delays [Demirhan, 2003].
