viral vectors to enable circuit interrogation in NHPs. Here, we identified compartment-specific gene expression patterns for NHP matrix – STXBP6, GDA, and SEMA3E – and striosome – BACH2, KCNT1, KCNIP1, and KHDRBS3. Moreover, we found an extrastriosomal cell type, the D1/D2 hybrid, that expressed many of the genes associated with striosome, thus suggesting a possible homology to ‘exo-patch’ cells.26 We expect that understanding the regulatory vocabulary governing these gene expression patterns will reveal cell-type-specific enhancers that can be packaged into AAVs that grant molecular access to striosome and matrix MSNs in the NHP brain.
