study demonstrated that the expansion of the selected ADH1B rs1229984 haplogroup is more recent, around 2,800 years ago [Li and others 2011b]. Furthermore, although ADH1B rs1229984 originated in the ancestors of Sino-Tibetan populations and the high diversity is present in Tibetan ADH1B haplotypes, no selection was observed in modern Tibetans [Lu and others 2012]. Methods based to different selection statistics (e.g., population differentiation and haplotype lengths) were applied to genome-wide data and confirmed the positive selection signatures in ADH1B gene in Asians [Peter and others 2012; Wang and others 2014c]. Some authors also hypothesized that, within Asian ancestry, other types of natural selection for ADH1B rs1229984, together with positive selection, are also present, including stabilizing selection and divergent selection [Evsyukov and Ivanov 2013]. A recent investigation based on principal component analysis also reported a genome-wide significant signal of selection for ADH1B locus in Europeans, suggesting convergent evolution in Europe and East Asia [Galinsky and others 2016].
