Results from three survival models for each substance use variable are presented in Tables 4–8, all of which include risk group based on parent and cotwin substance dependence (AD, cannabis dependence or a combined phenotype). In Model I, risk group only is modeled. In Model II, parental separation is included as an additional predictor, with control variables including coparent substance use/disorder added in Model III. Below we provide detailed summary for alcohol use, with results of Model III only summarized for alcohol intoxication, smoking, regular smoking, and cannabis use.