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Chunk #14 — Methods and Results

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An analysis of identical single-nucleotide polymorphisms genotyped by two different platforms.
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or MERLIN. (NB: in both the raw and the cleaned Illumina data set, the mother's (10001581) genotype at rs958883 is recorded as 1/1 whereas in the raw and the cleaned Affymetrix data set, the mother's genotype at tsc0260848 is recorded as 1/1 and 0/0, respectively.) The identified double recombinants occur in individuals whose genotypes are consistent between the two platforms. There are 2 equally probable inferences: either offspring 10000170, 1000060, and 10001543 (all of whom are genotyped as 1/1 with both platforms) are double recombinants and offspring 10000432, 10000635, and 10000804 (all of whom are genotyped as 2/2 with the Affymetrix platform) are not double recombinants, or vice versa. The evidence suggests that the 2/2 genotypes give rise to the apparent double recombinations.