81% of the variance in externalizing behaviour(Krueger et al., 2002). Lastly, previous meta-analytical GWAS studies have successfully applied this joint analysis approach, by identifying additional loci associated with depressive symptoms and neuroticism(Okbay, Baselmans, et al., 2016). BroadABC thus focuses on the broad spectrum of ASB and currently consists of five discovery cohorts (combined, N=16,400) and three independent prediction and replication samples: i) a population-based sample, N=825; ii) a forensic sample, N=6220 iii); and a substance-dependent sample, N=2336. In total, BroadABC has genotypic and phenotypic data from 25,781 individuals across eight unique samples, making it the largest collective sample available to estimate the effects of genome wide genetic variants for ASB and testing for genetic overlap with other traits.
