only study is significant (p=0.01) and a subsequent test of age-by-study interaction was not significant. It is notable that DNA source (92% from blood, 8% from saliva/buccal swabs) was not a significant predictor (p=0.45). When only blood samples are analyzed, the age effect estimate is the same (to three decimal places) and the p-value is only slightly higher (4 × 10−15). Copy-number mosaics and aUPD, when tested separately, each have a significant age effect and similar odds ratios (p-value for gain=0.01, loss=5 × 10−11, aUPD=6 × 10−8; OR (95% CI) for gain = 1.032 (1.005 – 1.061), loss = 1.057 (1.039 – 1.075), aUPD = 1.056 (1.035 – 1.077).
