abstinent and nonabstinent alcohol-dependent study participants, particularly when depressiveness was included as a covariate. Abstinent alcoholics also have been reported to manifest increased resting interhemispheric high theta (6 to 7 Hz) coherence with a more posterior topography than control subjects (Porjesz and Rangaswamy 2007; Rangaswamy and Porjesz 2008b). This high-theta coherence phenotype was found to be associated with both a GABAA (GABRA2) and a cholinergic receptor (CHRM2) gene (see “Electrophysiological Measures as Endophenotypes for Alcoholism”).
