Variants of the genes for ALDH2 on chromosome 12q24.12 (e.g., rs671), ADH1B on chromosome 4q23 (e.g., rs1229984) and CYP2E1 on chromosome 10q26.3 (e.g., rs10776687) (Webb et al., 2011) are associated with increased alcohol responses and decreased AUD risks (Bujarski et al., 2015; Jaime et al., 2014; Kuo et al., 2008; Sartor et al., 2015). Those actions could interfere with identification of other genetic variants related to low sensitivity. The relationships of these gene variants to alcohol sensitivity have been supported by animal and human alcohol studies (e.g., Cook et al., 2005; Dickson et al., 2006; Fischer et al., 2007; McCarthy et al., 2010; Wall et al., 2005; Wend et al., 2009).
